¨  The Immunology Ph.D. Program

·  Prior studies and degrees needed

For a successful participation in this program, M.Sc. (in biology and chemistry), M.D., D.V. or D.D. degrees are accepted on the condition that the curriculum of the undergraduate programs of the applicant included chemistry, biochemistry and molecular biology as major subjects (basic immunology is preferred).

·  Features of the program

§  Objectives  This program offers training in different areas of immunology, which aim at the understanding of innate and adaptive immune functions and the links between the two systems. Communication pathways between the immune and nervous systems are also subjects of our research. The research involves classical immunological, molecular- and systems’ biology approaches, as well as, most of the modern cell analytical techniques (e.g. multi-parameter flow cytometry, confocal microscopic imaging, etc.).

§   Curriculum  The curriculum is assembled so that students can gain a detailed practical experience in state-of-art methodology used in the research project they join. On the other hand, they can get a firm knowledge, through seminar series and regular as well as one-time courses, about the up-to-date theoretical background of  immune functions (with emphasis on the current research projects on autoimmunity, biotechnological developments in vaccination, regulation of lymphocyte activation and cell death or regulation of the allergic response). Special courses will also be devoted to the new techniques, methods applied in the field of modern immunological research (cellular imaging, flow cytometry, proteomics, etc.).

§  Currently available projects  Students in the Immunology program are recommended to participate in the work of research groups at Eötvös Loránd University, but they may also join to research groups of the Hungarian Academy of Sciences which participate in the program. The research groups at the University pursue projects in studying regulation of and links between the innate and adaptive immune systems.

The immuno-biological problems in the focus of our projects:

Regulatory functions of the complement system in the humoral immune response and in the mouse EAE-model of Sclerosis Multiplex,

Receptor cross-talks (B cell-, complement-, and Fc-receptors) in the humoral immune response,

The role of Gab adaptor proteins in B cell activation,

Mechanism of inhibition of IgE-mediated mast cell activation by various peptides and peptidomimetics, Development of new inhibitors,

The role of various complement-components (such as C1q, MBL, ficolin, C3) and complement-binding structures (C3b-acceptors, C1q receptors etc.) in maturation of dendritic cells,

Investigation of the expression and role of complement receptors CR1 and CR2 in the onthogenesis of autoimmune diseases (RA, SLE),

Searching for signaling therapy targets in B cells, in autoimmune (SLE, RA) and tumor disease models,

Non-genomic (membrane, signaling) effects of steroid hormones (estrogens) on lymphocyte functions,

The role of cholesterol and sphingolipids in regulation of the antigen presentation, activation, differentiation and death of T cells,

Integration of the activation and death signal pathways, its role in shaping the T cell repertoire, modeling complex signal networks,

Immuno-biotechnology developments: epitope-targeting for modulation of the immune response (scFv, biotinylation/tetramer constructs, etc.).

 

·          Program head:

Anna Erdei,  Professor of Immunology

(anna.erdei@freemail.hu )

·          Program coordinator to be contacted:

János Matkó Ph.D, D.Sc., Research Professor
(
matko@cerberus.elte.hu)